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Related Experiment Video

Updated: Dec 25, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Radiation Therapy as a Modality to Create Abscopal Effects: Current and Future Practices.

Dennis Adjepong¹, Bilal Haider Malik²

¹Neurological Surgery, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

|March 29, 2020

Summary

The abscopal effect (AbE) is an immune response outside the irradiated area. This review aims to improve neurosurgeon and healthcare practitioner knowledge of AbE, identifying and addressing knowledge gaps.

Keywords:

abscopal response cytotoxic irradiated tumor radiation therapy tumor cells

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Area of Science:

Oncology
Immunology
Radiation Oncology

Background:

The abscopal effect (AbE) describes an immune response occurring outside of the irradiated tumor volume.
While radiation therapy stimulates the immune system, leading to AbE, key knowledge gaps persist.
Understanding AbE is crucial for advancing cancer treatment strategies.

Purpose of the Study:

To enhance neurosurgeons' and healthcare practitioners' understanding of the abscopal effect (AbE).
To identify and address existing gaps in the current knowledge of AbE.
To consolidate and present the latest information on AbE from medical literature.

Main Methods:

Literature review of medical journals.
Synthesis of updated information on the abscopal effect.
Analysis of existing knowledge gaps and potential solutions.

Main Results:

The review consolidates current understanding of AbE mechanisms and clinical observations.
Identified significant gaps in knowledge regarding AbE induction and clinical application.
Highlighted the need for further research and education for healthcare professionals.

Conclusions:

Improving healthcare practitioners' knowledge of AbE is essential for its effective utilization.
Further research is required to fully elucidate the mechanisms and optimize the clinical application of AbE.
Addressing knowledge gaps will facilitate the integration of AbE into standard cancer care.