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Fruit and Vegetable Intake and the Risk of Chronic Obstructive Pulmonary Disease: A Dose-Response Meta-Analysis of
Hongrui Zhai1, Yu Wang1, Wenjie Jiang1
1Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, Shandong 266021, China.
Abstract:
Object. Results on the associations of fruit and vegetable intake with risk of chronic obstructive pulmonary disease (COPD) are still in conflict. Hence, we conducted a meta-analysis to quantitatively evaluate the association between fruit and vegetable intake and the risk of COPD.
Methods:
PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched for relevant studies published up to September 2019. Combined relative risks (RRs) and 95% confidence intervals (CIs) were calculated with the random effects model (REM). Dose-response relationship was assessed by the restricted cubic spline model.
Results:
There are 8 studies involving 5,787 COPD cases among 244,154 participants included in this meta-analysis. For the highest versus the lowest level, the pooled RR of COPD was 0.75 (95% CI, 0.68-0.84; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; P non-linearity < 0.01).
Conclusions:
This meta-analysis indicates that fruit and vegetable intake might be related to a lower risk of COPD.
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