Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural History of Patients Eligible for PROTEUS Diagnosed with Prostate Cancer and Treated with Radical Prostatectomy Without Perioperative Systemic Treatment.

European urology focus·2026
Same author

Functional and omics-based rationale for the induction of BRCAness by androgen receptor pathway inhibitors to sensitize prostate cancer to PARP inhibition, regardless of HRR status.

British journal of cancer·2026
Same author

[Generational shift in clinical urological care: status quo in German urology].

Urologie (Heidelberg, Germany)·2026
Same author

Prostatic acid phosphatase: a rediscovered target in prostate cancer.

Nature reviews. Urology·2026
Same author

Intramedullary cannulated screw fixation for hand fractures: patient-reported, clinical and radiological outcomes at 5 year follow-up.

The Journal of hand surgery, European volume·2026
Same author

A Systematic Review Comparing Sex-Specific Outcomes of Prospective Clinical Trials and Subsequent Real-World Data Focusing on Systemic Treatment Options for Renal Cell Cancer.

Urologia internationalis·2026

Related Experiment Video

Updated: Dec 25, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.3K

[Salvage lymph node dissection for nodal recurrent prostate cancer].

Lara Franziska Stolzenbach1, Sophie Knipper1, Tobias Maurer1

  • 1Universitätsklinikum Hamburg-Eppendorf, Martini-Klinik, Hamburg.

Aktuelle Urologie
|March 29, 2020
PubMed
Summary

Salvage lymph node dissection (SLND) shows promise for recurrent prostate cancer detected by advanced imaging like PSMA PET/CT. Further prospective studies are needed to confirm its clinical benefit in selected patients.

More Related Videos

Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

8.8K
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

7.8K

Related Experiment Videos

Last Updated: Dec 25, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.3K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

8.8K
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

7.8K

Area of Science:

  • Urology
  • Nuclear Medicine
  • Oncology

Background:

  • Advanced imaging, including prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT), enables earlier detection of nodal recurrence in prostate cancer patients.
  • Metastasis-directed therapy, specifically salvage lymph node dissection (SLND), is being investigated for node-only recurrence, with some studies suggesting improved prognosis in select cases.
  • Current guidelines do not recommend SLND due to a lack of high-level evidence, as most existing studies are retrospective.

Purpose of the Study:

  • To critically review current data on SLND for nodal recurrent prostate cancer.
  • To focus on the role of imaging, the extent of dissection, and oncological outcomes.
  • To evaluate the potential of new surgical approaches like PSMA radioguided surgery.

Main Methods:

  • Review of European guidelines recommending PSMA PET/CT or choline PET/CT for suspected prostate cancer recurrence.
  • Analysis of current practices regarding the extent of SLND (bilateral vs. unilateral).
  • Consideration of emerging techniques such as PSMA radioguided surgery.

Main Results:

  • PSMA PET/CT demonstrates superior sensitivity and specificity compared to choline PET/CT for detecting recurrence and is the preferred imaging modality.
  • While bilateral SLND is common practice, unilateral SLND is also considered, and a prospective trial (ProSTone) is underway to clarify optimal approaches.
  • PSMA radioguided surgery shows potential for intraoperative lymph node metastasis detection, though long-term data are pending.
  • SLND achieves a notable biochemical response rate in carefully selected patients.

Conclusions:

  • SLND can yield respectable biochemical response rates in carefully selected prostate cancer patients with nodal recurrence.
  • PSMA PET/CT is the recommended imaging technique for guiding SLND.
  • Prospective studies are essential to precisely define the clinical utility and optimal application of SLND.