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Relationship between body mass index and ischaemic stroke in Chinese elderly hypertensive patients

Jiayi Huang1, Lin Liu1, Yu-Ling Yu1

  • 1Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong Academy of Medical Sciences, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, School of Medicine, South China University of Technology, Guangzhou, China.

Postgraduate Medical Journal
|March 30, 2020
PubMed

Insights

Obesity, measured by body mass index (BMI), increases the risk of ischaemic stroke (IS) in elderly Chinese patients with hypertension. Higher BMI categories significantly correlate with a greater incidence of IS.

Area of Science:

  • Gerontology
  • Cardiovascular Epidemiology
  • Public Health

Background:

  • Obesity is a known risk factor for ischaemic stroke (IS).
  • The specific relationship between body mass index (BMI) and IS risk in hypertensive elderly populations, particularly in China, requires further clarification.

Purpose of the Study:

  • To investigate the association between BMI and the incidence of IS.
  • To evaluate BMI as an independent risk factor for IS among elderly hypertensive patients in China.

Main Methods:

  • A cohort of 3315 hypertensive patients aged 60 years and above in China was followed for an average of 5.5 years.
  • Multivariate Cox regression analysis was employed to assess the association between BMI (continuous and categorical) and new-onset IS, with interaction tests for covariates.

Main Results:

  • A higher BMI was positively associated with an increased incidence of IS (HR=1.14; 95% CI: 1.05 to 1.34).
  • The highest BMI category (≥28 kg/m²) showed a strong association with increased IS risk compared to normal BMI (HR=1.36; 95% CI: 1.09 to 1.80).
  • BMI independently predicted IS risk across various subgroups, including males, smokers, drinkers, diabetics, and those with uncontrolled blood pressure or reduced kidney function.

Conclusions:

  • Body mass index is a significant and independent risk factor for ischaemic stroke in elderly hypertensive Chinese patients.
  • Elevated BMI poses a considerable threat to cardiovascular health in this demographic, highlighting the need for weight management strategies.
Abstract

Keywords:
hypertensionstroke medicine

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