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Related Experiment Video

Updated: Dec 25, 2025

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage.

Kaikai Chen¹, Jinbo Zhu¹, Filip Bošković¹

¹Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.

|April 1, 2020

Summary

Researchers developed DNA hard drives (DNA-HDs) for rewritable molecular memory. This system uses DNA nanotechnology and nanopore sensing for secure, easy data storage and retrieval at the molecular level.

Keywords:

DNA nanostructures DNA nanotechnology Molecular data storage Nanopore sensing Single-molecule

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Last Updated: Dec 25, 2025

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Published on: October 31, 2013

Area of Science:

Molecular nanotechnology
Biophysics
Data storage technologies

Background:

Nanopores offer label-free sensing of nanoscale molecules like DNA.
DNA nanotechnology enables the creation of designed nanostructures and computations.
Molecular storage systems face challenges in rewritability and data access.

Purpose of the Study:

To introduce a rewritable molecular memory system using DNA nanotechnology and nanopore sensing.
To enable storing, operating, and reading data within a changeable DNA structure.
To enhance data writing/erasing efficiency and enable secure data access.

Main Methods:

Development of DNA hard drives (DNA-HDs) based on DNA nanotechnology.
Utilizing controllable attachment and removal of molecules on double-stranded DNA for data manipulation.
Employing nanopore sensing for millisecond-timescale detection of single DNA molecules for data reading.

Main Results:

Demonstrated a rewritable molecular memory system with improved data writing and erasing capabilities.
Achieved secure data storage requiring specific molecular keys for access.
Enabled easy-writing and easy-reading of data with potential for miniature scale integration.

Conclusions:

DNA hard drives offer a promising approach for rewritable, secure, and efficient molecular data storage.
The integration of DNA nanotechnology and nanopore sensing advances molecular computing and memory.
This technology paves the way for miniature-scale molecular data storage and computation solutions.