Related Experiment Video

Updated: Dec 25, 2025

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

446

[Bronchopulmonary dysplasia (BPD)]

E Herting1

  • 1Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Deutschland.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|April 1, 2020
PubMed

Insights

Bronchopulmonary dysplasia (BPD) has evolved from an old form linked to mechanical ventilation to a new form in premature infants. New BPD survivors face long-term multisystem health challenges.

Area of Science:

  • Neonatal medicine
  • Pediatric pulmonology
  • Developmental biology

Context:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
  • Historically, 'old' BPD resulted from mechanical ventilation and oxygen, causing lung fibrosis.
  • Modern surfactant therapy has increased survival, leading to 'new' BPD, characterized by impaired alveolar and capillary development.

Purpose:

  • To differentiate between the historical and current forms of BPD.
  • To highlight the distinct pathological mechanisms and clinical implications of 'new' BPD.
  • To underscore the long-term health consequences for survivors.

Summary:

  • 'Old' BPD was a fibroproliferative lung disease in premature infants due to ventilation and oxygen.
  • 'New' BPD, emerging with increased survival from surfactant therapy, involves arrested lung development and multisystem immaturity.
  • Survivors of 'new' BPD may experience persistent lung, cardiovascular, growth, and neurodevelopmental issues into adulthood.

Impact:

  • Understanding the evolution of BPD is crucial for developing targeted therapies.
  • Recognizing the multisystem nature of 'new' BPD necessitates comprehensive long-term follow-up.
  • Research into growth factors and stem cells shows promise for future BPD treatment strategies.
Abstract

Keywords:
Long-term outcomeLungLung diseasesPremature infantsRespiratory function

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