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Related Experiment Video

Updated: Dec 25, 2025

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

[Bronchopulmonary dysplasia (BPD)].

¹Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Deutschland.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde

|April 1, 2020

Summary

Bronchopulmonary dysplasia (BPD) has evolved from an old form linked to mechanical ventilation to a new form in premature infants. New BPD survivors face long-term multisystem health challenges.

Keywords:

Long-term outcome Lung Lung diseases Premature infants Respiratory function

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Published on: March 6, 2019

Area of Science:

Neonatal medicine
Pediatric pulmonology
Developmental biology

Context:

Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
Historically, 'old' BPD resulted from mechanical ventilation and oxygen, causing lung fibrosis.
Modern surfactant therapy has increased survival, leading to 'new' BPD, characterized by impaired alveolar and capillary development.

Purpose:

To differentiate between the historical and current forms of BPD.
To highlight the distinct pathological mechanisms and clinical implications of 'new' BPD.
To underscore the long-term health consequences for survivors.

Summary:

'Old' BPD was a fibroproliferative lung disease in premature infants due to ventilation and oxygen.
'New' BPD, emerging with increased survival from surfactant therapy, involves arrested lung development and multisystem immaturity.
Survivors of 'new' BPD may experience persistent lung, cardiovascular, growth, and neurodevelopmental issues into adulthood.

Impact:

Understanding the evolution of BPD is crucial for developing targeted therapies.
Recognizing the multisystem nature of 'new' BPD necessitates comprehensive long-term follow-up.
Research into growth factors and stem cells shows promise for future BPD treatment strategies.