Varying antibody response in hospital staff vaccinated against hepatitis B

Staff from a Department of Infectious Diseases (n = 64) were vaccinated against hepatitis B with HBVax (Merck, Sharp & Dohme), a plasma derived vaccine. Prevaccination testing showed a low prevalence of hepatitis B virus markers (1.4%). Only 1 person showed signs of anamnestic antibody response. Post-exposure prophylaxis and strict hygienic routines are recommended for non-operating hospital staff in areas with low prevalence of hepatitis B virus carriers. The anatomic site of intramuscular administration of the vaccine is discussed. The overall antibody response was low, 83% acquired a protective titer of anti-HBs and only 44% in the age group greater than 40 years of age. Postvaccination testing seems strongly advisable, especially in an older age group.