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Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased

Nikolaus Osterrieder1, Dusan Kunec1

  • 1Institut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany.

Current Clinical Microbiology Reports
|April 1, 2020
PubMed
Abstract

Keywords:
Codon biasCodon pair biasCpG dinucleotidesLarge-scale recodingLive modified virus vaccinesSynthetic attenuation virus engineering

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