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Related Experiment Video

Updated: Dec 25, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

Published on: April 18, 2025

Metal-based imaging agents: progress towards interrogating neurodegenerative disease.

Adam C Sedgwick¹, James T Brewster, Peter Harvey

¹Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, USA. sessler@cm.utexas.edu.

Chemical Society Reviews

|April 1, 2020

Summary

This summary is machine-generated.

Metal-based imaging techniques offer novel ways to visualize biomarkers for central nervous system (CNS) neurodegenerative diseases. This review explores how positron emission tomography (PET), MRI, and other methods aid in understanding disease progression.

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Last Updated: Dec 25, 2025

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Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS

Published on: January 22, 2017

Area of Science:

Neuroscience
Medical Imaging
Biochemistry

Background:

Central nervous system (CNS) neurodegeneration involves complex pathological processes with unknown causes.
Understanding disease mechanisms is crucial for developing effective treatments.
Transition metals and lanthanide ions possess unique properties applicable to CNS imaging.

Purpose of the Study:

To review metal-based imaging techniques for studying neurodegenerative diseases.
To highlight methods visualizing neuropathological biomarkers.
To discuss the utility of molecular imaging agents in neurodegeneration research.

Main Methods:

Overview of imaging modalities: Positron Emission Tomography (PET), Single-Photon Emission Computed Tomography (SPECT), Magnetic Resonance Imaging (MRI), and Luminescent-based Imaging (LumI).
Exploitation of high receptor-biomarker binding affinity.
Utilization of specific molecular transformations for signal generation.

Main Results:

Demonstrations of visualizing specific neuropathological biomarkers using various metal-based imaging techniques.
Strategies leveraging molecular recognition and transformation for diagnostic signal changes.
Discussion of advantages and disadvantages of each imaging method.

Conclusions:

Metal-based imaging provides valuable tools for understanding neurodegenerative disease pathophysiology.
Further development of molecular imaging agents is essential for advancing neurodegeneration research.
These techniques offer new perspectives on the complexities of CNS disorders.