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Updated: Dec 25, 2025
Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(ii) in
Enrico Falcone1, Paulina Gonzalez, Lucie Lorusso
1Institut de Chimie, UMR 7177, CNRS, Université de Strasbourg, 4 Rue Blaise Pascal 67000, Strasbourg, France. pfaller@unistra.fr raibaut@unistra.fr.
Abstract:
The measurement of exchangeable Cu2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb3+ luminescent turn-off sensor for Cu2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu2+ detection in the presence of a biological fluorescent background.
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