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Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac

Magnus Nakrem Lyngbakken1,2, Erika Nerdrum Aagaard1,2, Brede Kvisvik1,2

  • 1Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.

Clinical Chemistry
|April 1, 2020
PubMed

Insights

Cardiac troponin I (cTnI) and T (cTnT) levels indicate different cardiovascular risks. cTnI better predicts subclinical left ventricular hypertrophy than cTnT in the general population.

Area of Science:

  • Cardiology
  • Biomarkers
  • Cardiovascular Disease

Background:

  • Cardiac troponin I (cTnI) and T (cTnT) correlate with cardiac outcomes but not closely in the general population.
  • Hypothesized that cTnI and cTnT are influenced by different cardiovascular (CV) and non-CV risk factors, reflecting distinct CV phenotypes.

Purpose of the Study:

  • To investigate the differential associations of cTnI and cTnT with CV and non-CV risk factors.
  • To determine the relationship between cTnI, cTnT, and subclinical cardiovascular disease, particularly left ventricular hypertrophy and dysfunction.

Main Methods:

  • Prospective observational study of 1236 women and 1157 men from the Akershus Cardiac Examination 1950 Study.
  • Measured cTnI and cTnT using last-generation assays in individuals without known CV disease.
  • Extensive CV phenotyping, including detailed echocardiography, was performed at baseline.

Main Results:

  • cTnI was measurable in 60.3% and cTnT in 72.5% of participants; moderate correlation (r=0.53).
  • cTnI associated with male sex, higher education, hypertension, and age; cTnT associated with eGFR.
  • Both troponins inversely associated with global longitudinal strain and positively with LV mass index (LVMI); cTnI association with LVMI was stronger.
  • cTnI improved diagnostic accuracy for LV hypertrophy, while cTnT did not.

Conclusions:

  • cTnI and cTnT concentrations are linked to subclinical LV hypertrophy and dysfunction in a community-based cohort.
  • cTnI demonstrates superior predictive value for subclinical left ventricular hypertrophy compared to cTnT.
Abstract

Keywords:
Cardiac troponinsCardiovascular disease predictionCommunity evaluationEchocardiography

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