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Reference values for quantitative parameters in renal scintigraphy with Tc-99m-MAG3
Friederike Eilsberger1, Constantin Reiber1, Markus Luster1
1Nuclearmedicine, University of Marburg, Germany.
This study establishes crucial reference values for Mercaptoacetyltriglycin (MAG3) renal scintigraphy, enhancing diagnostic accuracy and standardization in clinical practice for both adults and children.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Diagnostic Imaging
Background:
- Standardized reference values improve comparability in diagnostic imaging.
- Renal Mercaptoacetyltriglycin (MAG3)-scintigraphy lacks established clinical routine reference values despite benefits.
- Establishing these values is key for consistent interpretation.
Purpose of the Study:
- To define reference values for key quantitative parameters in MAG3 renal scintigraphy.
- To improve and simplify the interpretation of MAG3 scintigraphy results in clinical practice.
- To enhance inter-institutional comparability and examiner independence.
Main Methods:
- Retrospective analysis of 247 MAG3 renal scintigraphies (01/2014-08/2017).
- Inclusion of non-pathological cases across a wide age range (25 days to 88 years).
- Analysis of Tmax and the 20-minute count ratio (Tmax) according to German Association for Nuclear Medicine guidelines.
Main Results:
- Defined reference values for Tmax and the 20-minute/Tmax count ratio in adults (>18 years) by age categories.
- Established Tmax reference values for pediatric age groups (0-0.5 years and 0.5-2 years).
Conclusions:
- The established reference values show high consistency with prior studies, confirming their reliability.
- These values are clinically feasible and aid in simplified and improved MAG3 renal scintigraphy interpretation.
- The findings support the use of these reference values as a valuable diagnostic tool.
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