dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions
Chang Li1, Chengcheng Mou2, Michael D Swartz3
1USF Genomics, College of Public Health, University of South Florida, Tampa, Florida.
Human Mutation
|April 1, 2020
Summary
This study introduces dbMTS, a database for genetic mutations in microRNA target sites. It helps researchers identify and prioritize single nucleotide variants that impact microRNA regulation of gene expression.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- MicroRNAs (miRNAs) are crucial regulators of gene expression, primarily by binding to the 3'-untranslated regions (UTRs) of messenger RNAs (mRNAs).
- Genetic variations, specifically single nucleotide variants (SNVs), within these miRNA target sites (MTS) can alter miRNA binding and consequently affect gene regulation.
Purpose of the Study:
- To develop and present dbMTS, a comprehensive database for SNVs located in MTS.
- To provide functional annotations for these SNVs to aid in understanding their impact on miRNA regulation.
Main Methods:
- Curated a database of MTS SNVs and their associated functional information.
- Developed a web service and downloadable database for easy access and utilization.
Main Results:
- dbMTS offers a centralized resource for identifying and analyzing SNVs that potentially disrupt miRNA-mRNA interactions.
- The database facilitates the prioritization of functionally significant SNVs for further research.
Conclusions:
- dbMTS serves as a valuable tool for researchers investigating the role of genetic variations in miRNA-mediated gene regulation.
- The database supports the study of genetic mutations impacting gene expression and disease.
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