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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Related Experiment Video

Updated: Dec 25, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

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Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers.

Rui Chen1, Wei-Qing Zhao1, Cheng Fang1

  • 1Department of Oncology, the Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, No. 185 Juqian Road, Tianning District, Changzhou 213003, China.

Journal of Cancer
|April 2, 2020
PubMed
Summary

The histone methyltransferase SETD2 is crucial for epigenetic regulation in cancers. Its mutation or loss of function in solid tumors suggests SETD2 acts as a tumor suppressor, impacting tumorigenesis and prognosis.

Keywords:
MutationSETD2Solid cancersTumor suppressor

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Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry
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Last Updated: Dec 25, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry
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Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry

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Area of Science:

  • Epigenetics and Cancer Biology
  • Molecular Oncology

Background:

  • Histone methylation is vital in cancer development and treatment.
  • SETD2, a histone H3 lysine 36 methyltransferase, regulates transcription and DNA repair.
  • SETD2 mutations are frequent in various solid tumors, impacting cancer progression.

Purpose of the Study:

  • To review the latest findings on SETD2 expression in solid cancers.
  • To explore the molecular and cellular functions of SETD2.
  • To discuss the clinical applications of SETD2 in cancer therapy.

Main Methods:

  • Review of high-throughput sequencing data.
  • Analysis of mRNA and protein expression levels of SETD2.
  • Literature review of molecular and cellular functions.

Main Results:

  • SETD2 mutations or functional loss are observed in renal, gastrointestinal, lung, and pancreatic cancers, among others.
  • Altered SETD2 function contributes to tumorigenesis, progression, and chemotherapy resistance.
  • SETD2 likely functions as a tumor suppressor, though mechanisms require further investigation.

Conclusions:

  • SETD2 plays a significant role in epigenetic regulation and tumor suppression.
  • Understanding SETD2's functions offers potential for novel cancer treatment strategies.
  • Further research is needed to elucidate SETD2's precise mechanisms in tumorigenesis.