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Mepanipyrim (Pesticides)

    Food Safety (Tokyo, Japan)
    |April 2, 2020
    PubMed

    Insights

    The Food Safety Commission of Japan assessed mepanipyrim fungicide, finding liver and kidney effects in rats but no reproductive or genetic toxicity. An acceptable daily intake (ADI) and acute reference dose (ARfD) were established.

    Area of Science:

    • Food Safety
    • Toxicology
    • Risk Assessment

    Background:

    • Mepanipyrim (CAS No. 110235-47-7) is an anilinopyrimidine fungicide.
    • Dietary risk assessment requires evaluating potential adverse effects of pesticide residues.

    Purpose of the Study:

    • To conduct a comprehensive risk assessment of mepanipyrim.
    • To establish an acceptable daily intake (ADI) and an acute reference dose (ARfD) for mepanipyrim.

    Main Methods:

    • Reviewed various toxicological studies on mepanipyrim.
    • Utilized a two-year combined chronic/carcinogenicity study in rats to determine the no-observed-adverse-effect level (NOAEL).
    • Employed an acute neurotoxicity study in rats to identify the lowest NOAEL for single oral administration.

    Main Results:

    • Major adverse effects in rats included hepatocellular hypertrophy, hepatocellular degeneration, and increased kidney weight.
    • No reproductive toxicity, teratogenicity, or genotoxicity was observed.
    • The NOAEL from the chronic study was 7.34 mg/kg bw/day, leading to an ADI of 0.073 mg/kg bw/day.
    • The lowest NOAEL from acute neurotoxicity was 400 mg/kg bw, resulting in an ARfD of 4 mg/kg bw.

    Conclusions:

    • Mepanipyrim (parent compound) is the relevant entity for residue definition in dietary risk assessment.
    • The established ADI and ARfD provide safety guidelines for mepanipyrim exposure.
    • The risk assessment supports the safe use of mepanipyrim within specified limits.

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