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Updated: Dec 25, 2025
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Avocado Sample Preparation Using the QuEChERS Method with Ammonium Formate for Pesticide Analysis
Published on: December 8, 2023
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Summary
The Food Safety Commission of Japan assessed the fungicide isofetamid, finding liver and thyroid effects but no genotoxicity or carcinogenicity. An acceptable daily intake (ADI) and acute reference dose (ARfD) were established for dietary risk assessment.
Area of Science:
- Food safety assessment
- Toxicology
- Risk analysis
Background:
- Isofetamid is a phenacyl amide fungicide.
- Risk assessment is crucial for agricultural products.
Purpose of the Study:
- To conduct a risk assessment of isofetamid (CAS No. 875915-78-9).
- To establish dietary exposure limits for isofetamid.
Main Methods:
- Review of various toxicity studies.
- Identification of the relevant substance for residue definition.
- Calculation of no-observed-adverse-effect levels (NOAELs).
Main Results:
- Observed effects: hepatocellular hypertrophy (liver) and follicular epithelial cell hypertrophy (thyroid).
- No observed neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, immunotoxicity, or genotoxicity.
- Lowest NOAEL: 5.34 mg/kg bw/day (1-year dog study).
- Lowest NOAEL for acute effects: 300 mg/kg bw/day (maternal toxicity in rabbits).
Conclusions:
- Parent isofetamid is the relevant substance for dietary risk assessment.
- Established Acceptable Daily Intake (ADI): 0.053 mg/kg bw/day.
- Established Acute Reference Dose (ARfD): 3 mg/kg bw/day.
