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Published on: May 15, 2012
Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids
Kai Tian1, Youchao Deng1, Lin Qiu1
1Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013 (China).
Abstract:
Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with varying aminobenzoic acids were semisynthesized. In contrast to all the previous reported inactive aminobenzaote analogues, a few of them showed moderate antibacterial activities against S. aureus. Our study suggested that modification of the conserved aminobenzoic acid remains a viable approach to diversify the PTM scaffold.
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