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Association between sarcoidosis and cardiovascular comorbidity: A systematic review and meta-analysis

Abdalla Reda Mahmoud1, Abdullah Dahy1, Mahmoud Dibas2

  • 1Faculty of Medicine, Minia University, Minia, Egypt.

Heart & Lung : the Journal of Critical Care
|April 3, 2020
PubMed

Insights

This study found that sarcoidosis is linked to increased risks of heart failure and hypertension. Early diagnosis and management of cardiovascular issues in sarcoidosis patients are crucial for better outcomes.

Area of Science:

  • Cardiology
  • Pulmonology
  • Systematic Review

Background:

  • Cardiovascular involvement in sarcoidosis significantly impacts patient morbidity and mortality.
  • Effective management strategies are essential for patients with cardiac sarcoidosis.

Purpose of the Study:

  • To determine the prevalence of cardiovascular comorbidities in sarcoidosis patients.
  • To analyze the association between sarcoidosis and various cardiovascular conditions.

Main Methods:

  • A systematic review and meta-analysis of 14 studies.
  • Electronic searches across nine databases.
  • Quality assessment using the National Institute of Health tool.

Main Results:

  • Hypertension (28.8%), heart failure (9.3%), and arrhythmia (8.1%) were the most common comorbidities.
  • Sarcoidosis showed a significant association with heart failure (OR=2.10) and hypertension (OR=1.27).
  • No significant association was found with cerebrovascular disease, ischemic heart disease, or ventricular tachycardia.

Conclusions:

  • Sarcoidosis is associated with specific cardiovascular comorbidities, notably heart failure and hypertension.
  • Prompt diagnosis and aggressive management are vital to mitigate risks in affected individuals.
Abstract

Keywords:
CardiovascularSarcoidosisSystematic review

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