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Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

Choongho Lee1

  • 1College of Pharmacy, Dongguk University, Goyang 10326, Korea.

Nutrients
|April 3, 2020
PubMed

Insights

Vitamin D (VD) and its related genes (VDRG) influence viral infections. This review clarifies their complex roles in viral disease progression and treatment, aiding evidence-based recommendations for patients.

Area of Science:

  • Nutritional Immunology
  • Molecular Virology
  • Genetics

Background:

  • Vitamin D (VD) is crucial for bone health and mineral homeostasis.
  • VD-related genes (VDRG) are vital for VD metabolism and function.
  • Emerging evidence links VD and VDRG to immune regulation and viral disease control.

Purpose of the Study:

  • To systematically review and compare the impact of VD and VDRG polymorphisms on viral infections.
  • To resolve inconsistencies in existing research regarding VD's role in viral pathogenesis.
  • To provide current information on VD and VDRG in managing viral diseases.

Main Methods:

  • Extensive literature search on PubMed using relevant keywords.
  • Analysis of research papers focusing on viral infections and VD/VDRG.
  • Comparative summary of VD and VDRG effects across various viral diseases.

Main Results:

  • VD and VDRG polymorphisms show varied effects on viral infection, pathogenesis, and treatment outcomes.
  • Specific viral diseases examined include hepatitis, respiratory infections, AIDS, herpesviruses, dengue, rotavirus, and HPV.
  • Inconsistencies in research findings highlight the complexity of VD's role.

Conclusions:

  • VD and VDRG play significant, albeit complex, roles in managing viral infections.
  • Evidence-based recommendations for VD use in virally infected patients are needed.
  • Further research is warranted to fully elucidate the therapeutic potential of VD and VDRG.
Keywords:
pathogenesistreatment outcomeviral infectionvitamin D (VD)vitamin D-related genes (VDRG)

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