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Hyperthermia with radiotherapy.

B C Tan1, T H Khor, K B Chia

  • 1Department of Therapeutic Radiology, Singapore General Hospital.

Annals of the Academy of Medicine, Singapore
|October 1, 1988
PubMed
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This study combined radiofrequency hyperthermia with radiation therapy for radioresistant tumors. Moderate hyperthermia was achieved in most patients, resulting in a 75% overall response rate.

Area of Science:

  • Oncology
  • Medical Physics

Background:

  • Hyperthermia combined with radiotherapy is studied for radioresistant tumors.
  • Advanced tumor recurrences and radioresistant types were selected.

Purpose of the Study:

  • To evaluate the efficacy of radiofrequency (RF) hyperthermia combined with radiation therapy.
  • To assess treatment response and identify technical challenges in delivering hyperthermia.

Main Methods:

  • A preliminary, non-controlled study involving 27 patients.
  • Used an 8MHz RF capacitive heating machine with inserted temperature probes.
  • Patients received hyperthermia and radiation therapy under local anesthesia.

Main Results:

  • 20 patients completed the study; 7 withdrew due to heat intolerance, 3 had skin burns.

Related Experiment Videos

  • Moderate hyperthermia was achieved in most cases.
  • A 75% overall response rate was observed (2 complete, 13 partial responses).

    • Conclusions:

    • RF hyperthermia combined with radiation shows promise for radioresistant tumors.
    • Technical challenges include probe insertion and uniform heating; improvements are needed.
    • Further clinical trials are necessary to optimize hyperthermia techniques.