Related Experiment Video
Updated: Dec 25, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
[Alcohol use disorder: evolution of the nosography]
Maurice Dematteis1, Lucie Pennel1, Georges Brousse2
1CHU Grenoble Alpes, service universitaire de pharmacoaddictologie ; université Grenoble Alpes, UFR de médecine, Grenoble, France.
The DSM-5 reclassified alcohol use disorder, moving from a hierarchical abuse/dependence model to a dimensional continuum. This evolution better integrates craving and supports diverse therapeutic strategies beyond abstinence.
Area of Science:
- Psychiatry
- Addiction Medicine
- Behavioral Science
Background:
- The Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) used a hierarchical classification for alcohol use.
- This system distinguished between alcohol abuse and alcohol dependence, often carrying stigma.
- The previous model did not fully integrate key concepts like craving.
Purpose of the Study:
- To analyze the nosographic shift in alcohol use disorder classification with the introduction of the DSM-5.
- To highlight the implications of the DSM-5's dimensional approach for understanding and treating addictive behaviors.
- To compare the DSM-5 framework with international standards like the ICD-10 and ICD-11.
Main Methods:
- Comparative analysis of diagnostic criteria between DSM-IV-TR and DSM-5.
- Review of the integration of craving as a diagnostic element.
- Examination of the dimensional perspective in classifying addictive behaviors.
Main Results:
- The DSM-5 abandoned the biaxial view and hierarchical gradation of abuse and dependence.
- The term "dependence" was removed, reducing stigma and clarifying psychic and physical dependency distinctions.
- Craving was integrated, aligning the DSM-5 with the ICD classification systems.
Conclusions:
- The DSM-5 represents a significant evolution in alcohol use disorder nosography, adopting a modern dimensional view.
- This progressive continuum from use to use disorder (mild to severe) allows for dynamic representation of addiction.
- The new framework supports tailored therapeutic strategies, including harm reduction and abstinence as one option.
More Related Videos
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
Related Concept Videos
Diagnostic and Statistical Manual of Mental Disorders (DSM)
CNS Depressants: Alcohol and Nicotine
Drug Abuse and Addiction: Pharmacological Phenomena
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Structure and Nomenclature of Alcohols and Phenols
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and...
Drug Dependence