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Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during

Dominik Denzel1, Lejla Colic1,2, Liliana Ramona Demenescu1

  • 1Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany.

The European Journal of Neuroscience
|April 3, 2020
PubMed
Summary

Glutamate (Glu) levels in specific cingulate cortex regions influence brain activity during emotion perception. Lower Glu in the pregenual anterior cingulate cortex (pgACC) relates to frontal activation, while anterior midcingulate cortex (aMCC) Glu affects posterior cingulate cortex (PCC) responses.

Keywords:
affect face matchingcingulate cortexglutamateregional specificity

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Metabolic Psychiatry

Background:

  • The cingulate cortex plays a crucial role in emotion recognition and regulation, with distinct rostral and caudal subregions involved in different affective processing networks.
  • While the impact of cingulate cortex glutamate (Glu) on blood-oxygen-level-dependent (BOLD) responses is acknowledged, the specific roles of subregional Glu levels during emotional tasks remain underexplored.

Purpose of the Study:

  • To investigate the subregion-specific associations between glutamate concentrations in the pregenual anterior cingulate cortex (pgACC) and anterior midcingulate cortex (aMCC) and BOLD responses during emotional perception.
  • To determine how these Glu levels correlate with brain activation patterns and behavioral responses to affective facial expressions.

Main Methods:

  • Seventy-two healthy participants underwent 7 Tesla magnetic resonance spectroscopy (MRS) and performed an affective face-matching task.
  • Correlations between BOLD responses during emotion perception and regional Glu concentrations in the pgACC and aMCC were analyzed.
  • Post hoc analyses assessed the specificity of these associations with different affective stimuli.

Main Results:

  • Lower Glu levels in the pgACC were associated with greater BOLD activation differences between negative and positive faces in the left inferior and superior frontal gyri.
  • Lower Glu levels in the aMCC correlated with BOLD responses in the posterior cingulate cortex (PCC).
  • Detection of negative faces was linked to increased response times (RT).

Conclusions:

  • Cingulate cortex glutamate exhibits subregion-specific relationships with brain activity during the perception of affective facial expressions.
  • pgACC glutamate influences frontal brain activations, whereas aMCC glutamate modulates responses in the PCC-precuneus network.
  • Region-specific metabolite mapping provides insights into the neural mechanisms underlying emotional perception and interindividual differences.