Related Experiment Video
Updated: Dec 25, 2025

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
Published on: January 15, 2017
[Bypass grafting in patients with infected vascular grafts]
V V Shlomin1, P D Puzdriak2, V S Cheplygin3
1Department of Vascular Surgery, Municipal Multimodality Hospital #2, Saint Petersburg, Russia; Department of Cardiovascular Surgery, North-Western State Medical University named after I.M. Mechnikov, Saint Petersburg, Russia.
Insights
Redo vascular graft interventions for infection are high-risk, with significant early and long-term mortality. However, bypass grafting, particularly with autologous vein, can be life-saving in complex cases.
Area of Science:
- Vascular Surgery
- Infectious Disease Management
- Graft Complication Treatment
Background:
- Synthetic vascular graft infections necessitate complex redo interventions.
- Patients presented with diverse complications including open wounds, fistulas, false aneurysms, and graft thrombosis.
- Aortofemoral prosthesis infections pose significant challenges in vascular reconstruction.
Purpose of the Study:
- To analyze outcomes of redo interventions for infected synthetic vascular grafts.
- To evaluate the efficacy and safety of various surgical techniques in managing graft infections.
- To identify factors influencing early and long-term mortality in these high-risk patients.
Main Methods:
- Retrospective analysis of 17 patients undergoing redo interventions for infected vascular grafts (2010-2018).
- Surgical procedures included subclavian-femoral bypass, crossover iliac-femoral bypass, unilateral iliac-femoral bypass, and loop endarterectomy.
- Bypass grafting through muscular lacunae was the predominant technique (14/17 patients).
Main Results:
- High early postoperative mortality (35%) due to acute renal failure, mesenteric thrombosis, gastrointestinal hemorrhage, and multiple organ failure.
- Significant long-term mortality (33% within 12 months) from renal failure, cardiovascular insufficiency, and respiratory insufficiency.
- Superficial femoral vein shunts showed good patency and infection resistance; omental/fat/muscular flaps improved graft tolerance to reinfection.
Conclusions:
- Redo interventions for infected vascular grafts carry substantial risks but are often necessary for limb or life salvage.
- Bypass grafting, despite its trauma, remains a critical option in complicated scenarios.
- Autologous vein grafts and tissue flaps enhance the durability and infection resistance of bypass reconstructions.
Abstract:
Analysed herein are the results of treating a total of 17 patients presenting with pathology of the aorta and lower-limb arteries, who from 2010 to 2018 required redo interventions due to infection of a previously implanted synthetic vascular graft. At admission, 3 patients were diagnosed as having an open infected wound, 11 were found to have a fistula, 2 had a false aneurysm in the area of the distal anastomosis of the branch of the bifurcation aortofemoral prosthesis, and 1 had thrombosis of the branch of the prosthesis with evidence of infection. As redo surgery, 4 patients underwent subclavian-femoral bypass grafting, 2 were subjected to crossover iliac-femoral bypass grafting, 8 to unilateral iliac-femoral bypass grafting, 3 to loop endarterectomy. In the majority of cases (14 of the 17) we used bypass grafting with creation of the tunnel through the muscular lacuna. Lethal outcomes were registered in 35% (n=6) of cases in the early postoperative period. Death was caused by acute renal failure in 6% (n=1), by acute mesenteric thrombosis in 12% (n=2), by gastrointestinal haemorrhage in 6% (n=1), and by multiple organ failure in 12% (n=2). Long-term mortality amounted to 33% (n=3) within 12 months. The main causes of death were increasing renal failure in 10% (n=1) and cardiovascular insufficiency on the background of heart diseases in 10% (n=1), as well as respiratory insufficiency in 10% (n=1). Reinfection in the remote period was diagnosed in 1 patient. A conclusion was drawn that bypass grafting is traumatic, however, it may be the only way to save the limb or patient's life in a complicated clinical situation. Using the superficial femoral vein as a shunt demonstrated good long-term results as to patency and resistance to surgical infection. Using a flap of the greater omentum, retroperitoneal fat, as well as wrapping of the prosthesis with a muscular flap ensured good tolerance of the zone of bypass grafting to reinfection.
Related Concept Videos
Hemodialysis I: Introduction
Peripheral Artery Disease V: Postoperative Nursing Management

