[Bypass grafting in patients with infected vascular grafts]

V V Shlomin1, P D Puzdriak2, V S Cheplygin3

  • 1Department of Vascular Surgery, Municipal Multimodality Hospital #2, Saint Petersburg, Russia; Department of Cardiovascular Surgery, North-Western State Medical University named after I.M. Mechnikov, Saint Petersburg, Russia.

Insights

Redo vascular graft interventions for infection are high-risk, with significant early and long-term mortality. However, bypass grafting, particularly with autologous vein, can be life-saving in complex cases.

Area of Science:

  • Vascular Surgery
  • Infectious Disease Management
  • Graft Complication Treatment

Background:

  • Synthetic vascular graft infections necessitate complex redo interventions.
  • Patients presented with diverse complications including open wounds, fistulas, false aneurysms, and graft thrombosis.
  • Aortofemoral prosthesis infections pose significant challenges in vascular reconstruction.

Purpose of the Study:

  • To analyze outcomes of redo interventions for infected synthetic vascular grafts.
  • To evaluate the efficacy and safety of various surgical techniques in managing graft infections.
  • To identify factors influencing early and long-term mortality in these high-risk patients.

Main Methods:

  • Retrospective analysis of 17 patients undergoing redo interventions for infected vascular grafts (2010-2018).
  • Surgical procedures included subclavian-femoral bypass, crossover iliac-femoral bypass, unilateral iliac-femoral bypass, and loop endarterectomy.
  • Bypass grafting through muscular lacunae was the predominant technique (14/17 patients).

Main Results:

  • High early postoperative mortality (35%) due to acute renal failure, mesenteric thrombosis, gastrointestinal hemorrhage, and multiple organ failure.
  • Significant long-term mortality (33% within 12 months) from renal failure, cardiovascular insufficiency, and respiratory insufficiency.
  • Superficial femoral vein shunts showed good patency and infection resistance; omental/fat/muscular flaps improved graft tolerance to reinfection.

Conclusions:

  • Redo interventions for infected vascular grafts carry substantial risks but are often necessary for limb or life salvage.
  • Bypass grafting, despite its trauma, remains a critical option in complicated scenarios.
  • Autologous vein grafts and tissue flaps enhance the durability and infection resistance of bypass reconstructions.