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ALBI versus child-pugh in predicting outcome of patients with HCC: A systematic review

Ying Peng1,2, Qinglin Wei1,2, Yonghong He1,2

  • 1Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University) , Chongqing, China.

Expert Review of Gastroenterology & Hepatology
|April 3, 2020
PubMed

Insights

The albumin-bilirubin (ALBI) score demonstrates superior ability in predicting outcomes for hepatocellular carcinoma (HCC) patients compared to the Child-Pugh score. Further research is needed to enhance prognostic accuracy for HCC.

Area of Science:

  • Hepatology
  • Oncology
  • Biomarker Research

Background:

  • Hepatocellular carcinoma (HCC) is a highly aggressive cancer with a poor patient prognosis.
  • The albumin-bilirubin (ALBI) score and Child-Pugh score are established tools for assessing prognosis in liver disease patients.
  • Comparing the prognostic predictive power of ALBI and Child-Pugh scores in HCC is crucial for clinical decision-making.

Purpose of the Study:

  • To systematically review and compare the prognostic discriminative ability of the ALBI score versus the Child-Pugh score in patients with hepatocellular carcinoma.
  • To evaluate the current effectiveness of these scoring systems in predicting HCC patient outcomes.

Main Methods:

  • A systematic literature search was conducted across major databases: PubMed, EMBASE, and Cochrane Library.
  • Relevant studies comparing the prognostic abilities of ALBI and Child-Pugh scores in HCC patients were identified and data extracted.
  • The extracted data were analyzed to assess the comparative predictive performance of the two scoring systems.

Main Results:

  • The systematic review indicated that the ALBI score possesses superior discriminative ability compared to the Child-Pugh score for predicting prognosis in HCC patients.
  • Despite ALBI's better performance, the overall predictive accuracy of both scores requires improvement for clinical utility.
  • The study highlights the need for more refined prognostic indicators in HCC management.

Conclusions:

  • The ALBI score is a more effective prognostic predictor than the Child-Pugh score in hepatocellular carcinoma.
  • Advanced genomic and molecular techniques, such as sequencing and methylation analysis, offer potential for discovering novel HCC biomarkers.
  • Future research should focus on validating new prognostic tools through multicenter prospective studies for early diagnosis and improved prognosis of HCC.
Abstract

Keywords:
Hepatocellular carcinomaalbumin to bilirubin ratiochild-Pughprognosissystematic review

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