Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
Master Transcription Regulators02:23

Master Transcription Regulators

2.6K
2.6K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.3K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.3K
General Transcription Factors01:30

General Transcription Factors

6.6K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.6K
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

17.9K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
17.9K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

10.6K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Systems Biology at 20: reflecting on the past, envisioning the future.

Molecular systems biology·2025
Same author

Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance.

Cell reports·2022
Same author

Altered expression response upon repeated gene repression in single yeast cells.

PLoS computational biology·2022
Same author

Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in <i>Saccharomyces cerevisiae</i>.

STAR protocols·2020
Same author

The past determines the future: sugar source history and transcriptional memory.

Current genetics·2020
Same author

Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory.

Molecular cell·2020
Same journal

Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate.

Molecular metabolism·2026
Same journal

Chronic Choline Restriction Remodels Hepatic Lipid Metabolism and Drives Insulin Resistance through a CD36-ETNPPL Regulatory Axis.

Molecular metabolism·2026
Same journal

Chronic semaglutide alters ingestive behavior without impairing taste function in mice.

Molecular metabolism·2026
Same journal

RNASET2 degrades mRNAs that protect against lipotoxicity.

Molecular metabolism·2026
Same journal

Corrigendum to "Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performance" [Mol Metabol (2025) 102207].

Molecular metabolism·2026
Same journal

Heterogeneous expression patterns of the T2D-associated kinesin-4 KIF21A in pancreatic islet endocrine cells.

Molecular metabolism·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.4K

Metabolic transcriptional memory.

Poonam Bheda1

  • 1Institute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany.

Molecular Metabolism
|April 3, 2020
PubMed
Summary
This summary is machine-generated.

Organisms exhibit metabolic transcriptional memory, retaining gene expression responses after metabolite removal. This microbial memory offers insights into human metabolic memory and diabetic complications.

Keywords:
BistabilityChromatin modificationDiabetesGalactoseGlucoseHyperglycemiaHysteresisInositolLactoseMaltoseMetabolic memoryMetabolic networkProtein inheritanceReinduction memoryTranscriptional memory

More Related Videos

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

4.2K
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.6K

Related Experiment Videos

Last Updated: Dec 25, 2025

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.4K
Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

4.2K
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.6K

Area of Science:

  • Molecular Biology
  • Microbiology
  • Genetics

Background:

  • Metabolic exposures can prime organisms to maintain gene expression responses even without the initial metabolite.
  • This metabolic transcriptional memory influences the speed and magnitude of gene expression during subsequent exposures.
  • Such memory is crucial for organism survival in dynamic environments.

Purpose of the Study:

  • To review examples of metabolic transcriptional memory in microbes.
  • To discuss underlying mechanisms including chromatin modifications, protein inheritance, and metabolic network changes.
  • To explore implications for human metabolic memory, particularly in diabetic complications.

Main Methods:

  • Review of microbial systems exhibiting metabolic transcriptional memory.
  • Analysis of mechanisms such as chromatin modifications and protein inheritance.
  • Discussion of conserved principles between microbial and human metabolic memory.

Main Results:

  • Examples of metabolic transcriptional memory in Escherichia coli and Saccharomyces cerevisiae involving carbon source shifts and sugar starvation.
  • Identification of conserved mechanisms like chromatin modifications and protein inheritance.
  • Parallels drawn between microbial metabolic memory and human hyperglycemic memory.

Conclusions:

  • Microbial metabolic transcriptional memory provides a model for understanding human metabolic memory.
  • Mechanistic insights from microbes are relevant to human diseases like diabetes.
  • Further study of microbial memory systems is key to understanding and treating human metabolic disorders.