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Updated: Dec 25, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
E-Cigarettes and Other Electronic Nicotine Delivery Systems (ENDS)
1Division of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, Boston Children's Health Physicians, Hawthorne, NY, USA; Division of Pediatric Pulmonology, Maria Fareri Children's Hospital at Westchester Medical Center, 40 Sunshine Cottage, Skyline 1NE-29, Valhalla, NY 10595, USA; Department of Pediatrics, New York Medical College, Valhalla, NY, USA.
Abstract:
Electronic nicotine delivery systems and vaping devices are now the most commonly used forms of tobacco consumed by youth and young adults. A variety of chemicals and toxicants released during inhalation have harmful systemic effects and effects on the lung. The known and potential health consequences are particularly alarming. There is concern that use of these devices will create a new generation of life-long smokers with nicotine and polysubstance addiction. Beyond the concerning chronic health effects of regular use, there is a recent epidemic of severe, acute lung disease termed e-cigarette, or vaping product use-associated lung injury, (EVALI), associated with high morbidity and mortality. These issues demand immediate public health attention. Healthcare providers play key roles in limiting the exposure of youth and young adults to these products by providing evidence-based counseling to patients and families, and by advocating for regulations to protect against childhood initiation and continuation of use.
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