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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Draft Genome Sequence of a Clostridioides difficile Sequence Type 97 Strain Belonging to Hypervirulent Clade 2

Yukino Usui1, Yoko Nukui2, Ryuji Koike2

  • 1Department of Molecular Microbiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Microbiology Resource Announcements
|April 4, 2020
PubMed

Insights

We sequenced the genome of Clostridioides difficile strain TMD0138 (ST97), a hypervirulent clade 2 strain from Japan. This provides crucial data for understanding C. difficile outbreaks globally.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Clostridioides difficile hypervirulent clade 2 lineages are major causes of outbreaks in North America and Europe.
  • Limited genome data exists for Japanese Clostridioides difficile isolates.

Purpose of the Study:

  • To report the draft genome sequence of a Japanese Clostridioides difficile hypervirulent clade 2 strain.

Main Methods:

  • Whole-genome sequencing of Clostridioides difficile strain TMD0138 (ST97).

Main Results:

  • The draft genome sequence of Clostridioides difficile strain TMD0138 (ST97), a hypervirulent clade 2 isolate from Japan, is now available.

Conclusions:

  • This genome data contributes to understanding the global epidemiology of Clostridioides difficile infections.
  • Facilitates comparative genomic studies of hypervirulent Clostridioides difficile strains.

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