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E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report
Laura E Crotty Alexander1,2, Lorraine B Ware3,4, Carolyn S Calfee5
1Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.
Summary
E-cigarette or vaping product use-associated lung injury (EVALI) research priorities were identified by experts. Urgent needs include patient registries, biospecimens for pathogenesis studies, and broader vaping research beyond smoking comparisons.
Area of Science:
- Pulmonology
- Public Health
- Toxicology
Background:
- E-cigarette or vaping product use-associated lung injury (EVALI) emerged as a significant public health concern.
- The complexity of the EVALI outbreak necessitated expert evaluation of research gaps and challenges.
Purpose of the Study:
- To identify urgent research priorities for EVALI.
- To recommend strategies for addressing EVALI's causal factors, diagnosis, treatment, and prevention.
Main Methods:
- Convened a multidisciplinary working group on October 23, 2019.
- Facilitated expert discussions on EVALI complexities and research needs.
Main Results:
- Identified critical research priorities, including establishing national and international patient registries.
- Highlighted the urgent need for biospecimens to elucidate EVALI pathogenesis.
- Recognized distinct disease risks associated with vaping compared to smoking.
Conclusions:
- Vaping presents unique disease risks, as evidenced by EVALI.
- Broadening e-cigarette research beyond smoking comparisons is crucial.
- Establishing patient registries and collecting biospecimens are key next steps for understanding and combating EVALI.
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