Related Experiment Video
Updated: Dec 25, 2025

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
Smart Soft Sensor Design with Hierarchical Sampling Strategy of Ensemble Gaussian Process Regression for Fermentation
Xiaochen Sheng1,2, Junxia Ma1,2, Weili Xiong1,2
1Key Laboratory of Advanced Process Control for Light Industry of Ministry of Education, Jiangnan University, Wuxi 214122, China.
This study introduces an active learning (AL) framework for smart soft sensors using ensemble Gaussian process regression (GPR). This approach enhances prediction accuracy and significantly reduces human annotation costs in industrial processes.
Area of Science:
- Industrial Process Control
- Machine Learning Applications
- Soft Sensor Technology
Background:
- Real-time quality prediction is crucial for optimal process control in Industrial 4.0.
- Traditional ensemble soft sensors struggle with limited labeled data, affecting prediction accuracy.
- Existing methods require significant human resources for data labeling and model development.
Purpose of the Study:
- To develop a novel active learning (AL) framework for smart soft sensor design.
- To overcome the limitations of traditional ensemble models dependent on labeled data.
- To reduce human annotation costs while maintaining high prediction performance.
Main Methods:
- An ensemble Gaussian process regression (GPR) model integrated with an active learning (AL) strategy.
- Hierarchical sampling for iterative selection of informative unlabeled samples.
- Gaussian Mixture Model (GMM) for autonomous operation phase identification and local GPR model construction.
- Bayesian fusion strategy for integrating base predictors.
Main Results:
- The proposed AL framework effectively handles complex nonlinearities and dynamic changes in industrial processes.
- Demonstrated significant reduction in human annotation costs (by at least half).
- Achieved high prediction performance comparable to or exceeding traditional methods.
Conclusions:
- The novel AL framework for ensemble GPR soft sensors offers a reliable and superior solution for industrial quality prediction.
- This approach significantly saves human resources and improves performance in complex industrial settings.
- The method is validated through comparative studies on a penicillin fermentation process.
More Related Videos
08:43PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis
Published on: May 11, 2017
11:59Extraction and Detection of Geosmin and 2-Methylisoborneol in Water and Fish using High-Capacity Sorptive Extraction Probes and GC-MS
Published on: July 3, 2025