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Related Experiment Videos

Hypoxic ventilatory response and acute mountain sickness.

J S Milledge1, P S Thomas, J M Beeley

  • 1Clinical Research Centre, Northwick Park Hospital, Harrow, Middx, UK.

The European Respiratory Journal
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

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Acute mountain sickness (AMS) susceptibility is not predicted by ventilatory responses to hypoxia (HVR) or hypercapnia (CO2VR). Respiratory acclimatization, not initial HVR, is likely key for altitude adaptation.

Area of Science:

  • Altitude Physiology
  • Respiratory Medicine
  • Mountaineering Medicine

Background:

  • Acute mountain sickness (AMS) is a common condition affecting individuals ascending to high altitudes.
  • Individual susceptibility to AMS varies significantly.
  • The role of baseline ventilatory responses in predicting AMS is not fully understood.

Purpose of the Study:

  • To investigate the relationship between acute ventilatory responses to hypoxia (HVR) and hypercapnia (CO2VR) and the development of AMS.
  • To determine if baseline HVR or CO2VR can predict AMS severity in mountaineers.
  • To explore the significance of respiratory acclimatization in altitude adaptation.

Main Methods:

  • Measured HVR and CO2VR in 32 mountaineers before high-altitude ascent.

Related Experiment Videos

  • Monitored AMS symptoms daily during rapid ascents to base camps at 5200 m and 4300 m.
  • Analyzed correlations between ventilatory responses and AMS symptom scores.

    • Main Results:

    • A wide spectrum of AMS severity was observed, from no symptoms to severe cases requiring evacuation.
    • No significant correlation was found between baseline HVR or CO2VR and AMS symptom scores.
    • Initial ventilatory responses measured at sea level did not predict AMS susceptibility.

    Conclusions:

    • Baseline acute ventilatory responses to hypoxia and hypercapnia do not appear to be major determinants of AMS susceptibility for rapid ascents.
    • The rate of respiratory acclimatization is likely a more critical factor in determining an individual's adaptation to high altitude.
    • Further research into acclimatization mechanisms is warranted.