Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

9.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.1K
Apoptosis01:30

Apoptosis

13.6K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
13.6K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.9K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.9K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

7.8K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
7.8K
Autophagic Cell Death01:18

Autophagic Cell Death

4.2K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.2K
Necrosis01:16

Necrosis

6.1K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DRP1 and MID49 co-diffusion scans mitochondria for fission.

Nature cell biology·2026
Same author

MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth.

Nature structural & molecular biology·2026
Same author

What does BCL-2 do? From new molecular insights to the clinical implications.

Cell death and differentiation·2026
Same author

Spotted: RIPK3 and MLKL assembling necroptotic complexes.

Open biology·2026
Same author

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.

Cell·2025
Same author

Mitochondrial dynamics and pore formation in regulated cell death pathways.

Trends in biochemical sciences·2025
Same journal

Advances in nano biomaterials for biomedical engineering.

International review of cell and molecular biology·2026
Same journal

MRI acute/sub-acute ischemic stroke segmentation with deep learning: A comprehensive review.

International review of cell and molecular biology·2026
Same journal

Bioink-based 3D bioprinting: Paving the path for regenerative medicine.

International review of cell and molecular biology·2026
Same journal

Advances in ferroptosis research and applications.

International review of cell and molecular biology·2026
Same journal

Neurodiagnostic: Advances in diagnostic tools.

International review of cell and molecular biology·2026
Same journal

Recent advances in nanomedicine as drug delivery system.

International review of cell and molecular biology·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

3.0K

A lipid perspective on regulated cell death.

Hector Flores-Romero1, Uris Ros1, Ana J García-Sáez1

  • 1Interfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.

International Review of Cell and Molecular Biology
|April 6, 2020
PubMed
Summary
This summary is machine-generated.

Lipids are crucial regulators of cell death, influencing membrane permeabilization and executor activation in apoptosis, necroptosis, and ferroptosis. Understanding lipid roles in membrane dynamics is key to regulating cell death processes.

Keywords:
ApoptosisFerroptosisMembrane dynamicsMitochondriaNecroptosisPlasma membraneRegulated cell death

More Related Videos

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

9.0K
Comprehensive Analysis of Drug Response using the FLICK Assay
09:42

Comprehensive Analysis of Drug Response using the FLICK Assay

Published on: June 6, 2025

616

Related Experiment Videos

Last Updated: Dec 25, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

3.0K
Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

9.0K
Comprehensive Analysis of Drug Response using the FLICK Assay
09:42

Comprehensive Analysis of Drug Response using the FLICK Assay

Published on: June 6, 2025

616

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Lipids are essential for cellular structure and signaling.
  • Lipid metabolism regulates critical cellular processes, including cell division, proliferation, and death.
  • Regulated cell death (RCD) pathways heavily rely on lipids for initiation and execution.

Purpose of the Study:

  • To elucidate the multifaceted roles of lipids in various forms of regulated cell death.
  • To highlight the contribution of lipids and membrane dynamics in cell death regulation.

Main Methods:

  • Review of existing literature on lipid involvement in apoptosis, necroptosis, and ferroptosis.
  • Analysis of lipid profiles and membrane permeabilization in different RCD types.
  • Examination of lipid-mediated activation of cell death executors.

Main Results:

  • Lipid membrane permeabilization is a common hallmark of RCD, with distinct lipid profiles for each death type.
  • Apoptosis involves mitochondrial outer membrane permeabilization, while necroptosis and ferroptosis involve plasma membrane permeabilization.
  • Lipids act as accessory molecules for activating key protein executors like BAX (apoptosis) and MLKL (necroptosis).
  • Phospholipid peroxidation and membrane destabilization are critical for ferroptosis induction.

Conclusions:

  • Lipids are indispensable players in the regulation of apoptosis, necroptosis, and ferroptosis.
  • Membrane dynamics and specific lipid profiles are central to the execution of distinct RCD pathways.
  • Further research into lipid roles can provide insights into therapeutic strategies targeting cell death.