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Non-coding RNAs: Regulators of valvular calcification

Shashi Kumar Gupta1, Sunaina Kumari1, Sandhya Singh1

  • 1Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India.

Journal of Molecular and Cellular Cardiology
|April 6, 2020
PubMed

Insights

Non-coding RNAs, particularly miR-214 and miR-204, are key regulators in valvular heart disease tissue remodeling. These molecules show potential for diagnosing and treating valvular calcification.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Valvular heart diseases are increasing globally, driven by aging and lifestyle changes.
  • These conditions involve aortic and mitral valve remodeling, including calcification and endothelial dysfunction.
  • Both protein-coding and non-coding genes regulate these pathological processes.

Purpose of the Study:

  • To review the role of non-coding RNAs in valvular tissue remodeling.
  • To explore the therapeutic potential of non-coding RNAs in valvular diseases.
  • To summarize the diagnostic utility of circulating non-coding RNAs.

Main Methods:

  • Literature review of studies on non-coding RNA in valvular heart disease.
  • Analysis of research on non-coding RNA regulation of valvular remodeling.
  • Evaluation of studies on diagnostic biomarkers and therapeutic targets.

Main Results:

  • Non-coding RNAs significantly mediate valvular tissue remodeling processes.
  • Specific microRNAs, including miR-214 and miR-204, are central regulators of valvular calcification.
  • Circulating non-coding RNAs show promise as diagnostic markers for valvular diseases.

Conclusions:

  • Non-coding RNAs represent crucial regulators and potential therapeutic targets for valvular heart diseases.
  • miR-214 and miR-204 are identified as key players in the pathogenesis of valvular calcification.
  • Further research into non-coding RNAs could lead to novel diagnostic and therapeutic strategies.

Keywords:
Circular RNALncRNAMicroRNANon-coding RNAValve calcificationValve stenosis

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