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Large check size pattern reversal visual evoked potentials - Full and sectorial field stimulation in multiple
Emily Cheung1, Jessica Hafner1, Yi-Ching Lee1
1Department of Neurology and Clinical Neurophysiology, Royal North Shore Hospital, Australia; The University of Sydney, Sydney, NSW, Australia.
Summary
Large check sizes in visual evoked potentials (VEP) testing reveal greater optic neuritis abnormalities with central field stimulation. This method enhances detection in multiple sclerosis patients, suggesting gender-specific normal values are needed.
Area of Science:
- Neuroscience
- Ophthalmology
- Clinical Electrophysiology
Background:
- Pattern reversal visual evoked potentials (VEP) are crucial for diagnosing optic neuritis.
- Traditionally, smaller check sizes are used, but larger sizes may aid fixation in patients with poor vision.
Purpose of the Study:
- To compare sectorial central and peripheral hemisurround stimuli with full- and half-field stimuli using large check sizes (65') for optic neuritis and multiple sclerosis.
- To evaluate the sensitivity of large check sizes in central visual field stimulation.
Main Methods:
- Utilized large check size (65') pattern reversal VEP stimuli.
- Compared sectorial central and peripheral hemisurround stimulation with full- and half-field stimulation.
- Analyzed VEP data from 35 control subjects (19 female, 16 male) and 18 patients with optic neuritis.
Main Results:
- Females exhibited shorter P100 latencies and larger amplitudes than males in control subjects.
- Central field stimulation with large checks revealed greater abnormalities than full-field stimulation in 9 out of 18 patients.
- This indicates central field stimulation is more sensitive for detecting abnormalities in optic neuritis.
Conclusions:
- Central field stimulation using large checks can detect a greater extent of abnormality in optic neuritis than large check full-field stimulation alone.
- This approach can improve diagnostic yield in investigating optic neuritis.
- Gender-specific normal values for large check size VEP are necessary for accurate interpretation.
