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Hyperkalemic periodic paralysis aggravated by voltage - gate sodium channel blocker antiepileptic drug?
S Zukić1, O Sinanović2, M Alečković-Halilović3
1Department of Neurology, University Clinical Centre Tuzla, Bosnia and Herzegovina.
Abstract:
Hyperkalemic periodic paralysis (hyperkalemic PP) is a rare muscle disease that has onset in infancy or early childhood and is manifested by transient episodes of paralysis. In this case we presented a young male adult with attacks of weakness, after commencement of the antiepileptic drug - Carbamazepine. We hypothesize that Carbamazepine, as voltage-gate sodium channel blocker, aggravated the symptoms of hyperkalemic PP, as sodium channelopathies, in this young-male-patient, trough influence on membrane depolarization.
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