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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilic colitis in adults.

Gilles Macaigne1

  • 1Service d'hépato-gastro-entérologie, Centre Hospitalier Marne-la-Vallée (GHEF), 2-4, cours de la Gondoire 77600 Jossigny, France.

Clinics and Research in Hepatology and Gastroenterology
|April 7, 2020
PubMed
Summary
This summary is machine-generated.

Eosinophilic colitis (EoC) is rare in adults, presenting with non-specific symptoms like diarrhea and abdominal pain. Diagnosis lacks consensus, but corticosteroids and budesonide show treatment promise.

Keywords:
AllergyCorticosteroidsPrimary and secondary eosinophilic colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Eosinophilic colitis (EoC) involves eosinophil infiltration of the colon.
  • While common in infants, EoC is less studied in adults.
  • EoC can be primary (allergic) or secondary.

Purpose of the Study:

  • To review the characteristics of eosinophilic colitis in adults.
  • To discuss diagnostic challenges and potential criteria.
  • To explore treatment options for adult EoC.

Main Methods:

  • Literature review of adult EoC cases.
  • Analysis of diagnostic criteria and histological findings.
  • Evaluation of treatment efficacy, including dietary and medical interventions.

Main Results:

  • Adult EoC symptoms are variable and non-specific (diarrhea, abdominal pain).
  • Diagnostic histological consensus is lacking; >40 eosinophils/HPF is proposed.
  • Allergic triggers are less frequently identified in adults, limiting dietary interventions.
  • Corticosteroids and budesonide demonstrate potential efficacy.

Conclusions:

  • Eosinophilic colitis in adults requires further research due to its rarity and diagnostic challenges.
  • Current diagnostic criteria are debated, with proposed histological thresholds.
  • While primary EoC is often allergic, adult cases may not have identifiable triggers, necessitating medical treatment, often with corticosteroids.