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Association between craniofacial morphological patterns and tooth agenesis-related genes
Amanda Silva Rodrigues1, Ellen Cardoso Teixeira2, Leonardo Santos Antunes2,3
1School of Dentistry, Fluminense Federal University, Rua São Paulo 28, Campus do Valonguinho, Niterói, RJ, 24020-150, Brazil.
Progress in Orthodontics
|April 7, 2020
Summary
Genetic variations in FGF3 may influence craniofacial development, specifically increasing the risk of skeletal class III malocclusion. This study investigated gene-polymorphism associations with tooth agenesis and facial patterns.
Area of Science:
- Genetics
- Craniofacial Morphology
- Dental Development
Background:
- Tooth agenesis (TA) is a common dental anomaly.
- Understanding genetic factors in TA is crucial for predicting craniofacial development.
- Previous research has identified several genes associated with TA.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in TA-related genes and craniofacial morphology.
- To determine if specific gene variants correlate with skeletal malocclusion and facial growth patterns.
Main Methods:
- A cross-sectional genetic study of 594 Brazilian orthodontic patients.
- Panoramic radiography for TA assessment and digital cephalometrics for craniofacial analysis.
- Genotyping of polymorphisms in MSX1, PAX9, TGF-α, FGF3, FGF10, and FGF13 genes using PCR and TaqMan chemistry.
Main Results:
- A significant association was found between the FGF3 rs1893047 polymorphism and skeletal malocclusion.
- Carrying the G allele of FGF3 rs1893047 increased the odds of skeletal class III malocclusion by over two times (OR = 2.21).
- No significant associations were observed for other assessed polymorphisms and craniofacial patterns.
Conclusions:
- The genetic polymorphism rs1893047 in FGF3 may play a role in craniofacial sagittal pattern variations.
- This finding highlights a potential genetic marker for skeletal class III malocclusion.
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