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Updated: Dec 25, 2025

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
MNA-SF is not sufficient without questioning protein and fruit-vegetable consumption to detect malnutrition risk in
Vasfiye Burcu Albay1, Mesude Tutuncu2
1Department of Neurology, Bakirkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Bitam Binası. Bakirkoy, 34147, Istanbul, Turkey. dr_burcuvdogan@hotmail.com.
Abstract:
Malnutrition risk (MR) prevalence in Parkinson's Disease (PD) is 3-60%. Mini-Nutritional Assessment (MNA) and MNA-SF are the widely Query used measurements for MR. The aim of this study was to identify if MNA-SF is sufficient to detect MR instead of total MNA in PD. Participants were compared in terms of anthropometric measurements, MNA (total, screening and evaluation), non-motor questionnaire, beck depression inventory, beck anxiety inventory. They were additionally compared according to evaluation part of MNA. All PD patients were divided into two groups as "with MR" and "without MR" according to total MNA scores and comparisons were done again. Then, IPD patients whose MNA-SF scores were normal were divided into another two subgroups as "with MR" and "without MR" according to total MNA scores and compared again. 58.7% PD patients and 28.6% controls were at MR. 32.5% PD patients whose MNA-SF scores were normal were detected as "with MR" by total MNA. MNA-SF had 87.1% sensitivity, 70.5% specificity, 67.5% positive predictive value, 88.6% negative predictive value and 77.3% accuracy in PD. PC and FVC were found to be the most important questions in MR estimation. Total MNA was sufficient to measure MR in PD, however MNA-SF missed many patients who were at MR. PC and FVC should be insistently questioned in addition to MNA-SF to find the accurate results of MR in PD patients, especially in females with higher disease severity and duration.
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