Long noncoding RNAs in osteosarcoma via various signaling pathways

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Osteosarcoma is a prevalent bone malignancy with unclear oncogenesis mechanisms.
• Long noncoding RNAs (lncRNAs) are increasingly recognized for their significant roles in osteosarcoma.
• Understanding lncRNA involvement is key to unraveling osteosarcoma development and progression.

Purpose of the Study:

• To review the multifaceted roles of lncRNAs in osteosarcoma pathogenesis.
• To elucidate how lncRNAs regulate critical signaling pathways in osteosarcoma.
• To explore the therapeutic potential of targeting lncRNAs in osteosarcoma.

Main Methods:

• Literature review of studies on lncRNAs and osteosarcoma.
• Analysis of lncRNA involvement in key signaling pathways (e.g., PI3K/Akt, Wnt/β-catenin, NF-κB, Notch, HIF-1α, P53, MAPK).
• Summarization of identified lncRNAs and their associated pathways.

Main Results:

• lncRNAs are deregulated in osteosarcoma, influencing its development, progression, and invasion.
• Specific lncRNAs (e.g., MALAT1, CCAT2, HOTAIR) modulate pathways crucial for osteosarcoma.
• lncRNAs participate in regulating PI3K/Akt, Wnt/β-catenin, NF-κB, Notch, HIF-1α, P53, and MAPK signaling.

Conclusions:

• lncRNAs are pivotal in osteosarcoma's molecular landscape.
• Targeting specific lncRNAs and their associated signaling pathways presents a promising therapeutic strategy for osteosarcoma.
• Further research into lncRNA functions can advance osteosarcoma treatment.