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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
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Long noncoding RNAs in osteosarcoma via various signaling pathways.

Jinming Han1, Xiaohan Shen2,3

  • 1Ningbo NO.6 Hospital, Ningbo, China.

Journal of Clinical Laboratory Analysis
|April 7, 2020
PubMed
Summary

Long noncoding RNAs (lncRNAs) are critical regulators in osteosarcoma development and progression. This review highlights their roles in various signaling pathways, offering potential therapeutic targets for this bone cancer.

Keywords:
lncRNAsosteosarcomasignaling pathway

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma is a prevalent bone malignancy with unclear oncogenesis mechanisms.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their significant roles in osteosarcoma.
  • Understanding lncRNA involvement is key to unraveling osteosarcoma development and progression.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in osteosarcoma pathogenesis.
  • To elucidate how lncRNAs regulate critical signaling pathways in osteosarcoma.
  • To explore the therapeutic potential of targeting lncRNAs in osteosarcoma.

Main Methods:

  • Literature review of studies on lncRNAs and osteosarcoma.
  • Analysis of lncRNA involvement in key signaling pathways (e.g., PI3K/Akt, Wnt/β-catenin, NF-κB, Notch, HIF-1α, P53, MAPK).
  • Summarization of identified lncRNAs and their associated pathways.

Main Results:

  • lncRNAs are deregulated in osteosarcoma, influencing its development, progression, and invasion.
  • Specific lncRNAs (e.g., MALAT1, CCAT2, HOTAIR) modulate pathways crucial for osteosarcoma.
  • lncRNAs participate in regulating PI3K/Akt, Wnt/β-catenin, NF-κB, Notch, HIF-1α, P53, and MAPK signaling.

Conclusions:

  • lncRNAs are pivotal in osteosarcoma's molecular landscape.
  • Targeting specific lncRNAs and their associated signaling pathways presents a promising therapeutic strategy for osteosarcoma.
  • Further research into lncRNA functions can advance osteosarcoma treatment.