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Updated: Dec 25, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Research Progress on Human Age Estimation Based on DNA Methylation.

Z H Wang¹, S J Li¹

¹College of Forensic Medicine of Hebei Medical University, Shijiazhuang 050017, China.

Fa Yi Xue Za Zhi

|April 7, 2020

Summary

This summary is machine-generated.

DNA methylation offers accurate and stable age estimation for forensic science. Recent advancements include specificity, multi-tissue analysis, and improved statistical models for reliable suspect profiling.

Keywords:

forensic genetics; DNA methylation; age determination; review

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Targeted DNA Methylation Analysis by Next-generation Sequencing

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Published on: February 24, 2015

Area of Science:

Forensic Science
Epigenetics
Biomolecular Analysis

Background:

Age is critical individual information in forensic investigations.
DNA methylation is emerging as a highly accurate and stable biomarker for age estimation.
Existing forensic methods require continuous improvement for suspect profiling.

Purpose of the Study:

To review recent progress in DNA methylation-based age estimation for forensic applications.
To summarize advancements in specificity, tissue applicability, and sensitivity of age estimation methods.
To highlight the development of robust statistical models and their forensic utility.

Main Methods:

Review of recent scientific literature on DNA methylation and age estimation.
Analysis of studies focusing on specificity of methylation sites.
Evaluation of statistical modeling techniques for age prediction.

Main Results:

Significant progress in identifying specific DNA methylation sites for age prediction.
Development of methods for age estimation across multiple tissues and in minors.
Establishment of more accurate statistical models, addressing platform differences and environmental influences.

Conclusions:

DNA methylation analysis provides a powerful tool for forensic age estimation.
Continued research is refining the accuracy, reliability, and applicability of these methods.
This review consolidates key findings to guide future forensic science research and practice.