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Related Experiment Video

Updated: Dec 24, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

INTRARETINAL HYPERREFLECTIVE LINES.

Francesca Amoroso¹, Sarah Mrejen², Alexandre Pedinielli¹

¹Department of Ophthalmology, University of Paris Est, Creteil, France.

Retina (Philadelphia, Pa.)

|April 7, 2020

Summary

This summary is machine-generated.

Intraretinal hyperreflective lines, observed in various macular conditions, may indicate damage to retinal cells. These lines can appear in degenerative, inflammatory, or tractional eye diseases.

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Last Updated: Dec 24, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Published on: January 12, 2022

Retinal Pathophysiological Evaluation in a Rat Model

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

Area of Science:

Ophthalmology
Retinal Imaging
Macular Diseases

Background:

Intraretinal hyperreflective lines are an optical coherence tomography finding.
Their association with diverse macular pathologies requires further investigation.

Purpose of the Study:

To document intraretinal hyperreflective lines in patients with various macular conditions.
To analyze the clinical presentation and imaging features of these lines.

Main Methods:

Retrospective analysis of 49 eyes from 43 patients.
Utilized color fundus photography, autofluorescence, spectral-domain optical coherence tomography, and angiography.
Collected demographic, imaging, clinical course, and outcome data.

Main Results:

Hyperreflective lines (vertical or curvilinear) were found in 49 eyes with conditions including adult vitelliform dystrophy, age-related maculopathy, hemorrhages, macular microhole, and vitreomacular traction.
Lines were frequently associated with epiretinal membranes and thick choroids in pattern dystrophy.
Lines resolved in cases of hemorrhage or resolved vitreomacular traction, but typically persisted and thinned in other conditions.

Conclusions:

Intraretinal hyperreflective lines can manifest in various inflammatory, degenerative, and tractional macular conditions.
These lines may represent an unrecognized response to damage in photoreceptors, Müller cells, or retinal pigment epithelium.