Related Experiment Video

Updated: Dec 24, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.9K

Association of miR-760 with cancer: An overview

Monika Kaushik Siddharth Manvati1, Juveria Khan1, Neeraj Verma1

  • 1School of Biotechnology, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India.

Gene
|April 7, 2020
PubMed

Insights

MicroRNA-760 (miR-760) is often downregulated in various cancers, suggesting its potential as a prognostic marker. This review explores miR-760's role in cancer progression, including cervical cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Dysregulated miRNA expression is implicated in various cancer hallmarks like proliferation, metastasis, and angiogenesis.
  • miRNAs play a significant role in modulating diverse disease processes.

Purpose of the Study:

  • To review the role of MicroRNA-760 (miR-760) in the progression of different cancers.
  • To highlight the potential of miR-760 as a prognostic marker for cancer detection.
  • To address the current knowledge gap regarding miR-760's function in cervical cancer.

Main Methods:

  • Literature review and data compilation on miR-760 expression in various cancers.
  • Analysis of existing studies focusing on miRNA dysregulation mechanisms in cancer.
  • Synthesis of information to understand miR-760's biological role in cancer regulation.

Main Results:

  • MicroRNA-760 (miR-760) is frequently downregulated across multiple cancer types.
  • Downregulation of miR-760 suggests its potential utility as a biomarker for cancer prognosis.
  • The review specifically examines the involvement of miR-760 in cervical cancer progression.

Conclusions:

  • miR-760's downregulated expression in cancers positions it as a potential prognostic indicator.
  • Further research into miR-760's function will enhance understanding of its regulatory role in cancer biology.
  • Investigating miR-760 in cervical cancer aims to fill a critical gap in current knowledge.
Keywords:
CancerNon-coding DNARegulationmiR-760micro RNAmicroRNA targets

More Related Videos

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.0K
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.9K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K