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Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

Xueshu Shi1, Yue Ma2, Haiyan Li3

  • 1Nursing Division, The second affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, P.R. China.

BMC Medical Genetics
|April 8, 2020
PubMed
Abstract

Insights

Genetic variations in MUC5B rs35705950 significantly increase pneumonia susceptibility, particularly idiopathic pulmonary fibrosis. FCGR2A rs1801274 showed no association with pneumonia risk in this meta-analysis.

Area of Science:

  • Genetics
  • Pulmonology
  • Epidemiology

Background:

  • Pneumonia susceptibility is influenced by genetic factors.
  • The roles of FCGR2A rs1801274 and MUC5B rs35705950 in pneumonia risk require comprehensive evaluation.
  • Published data on these genetic variations and pneumonia are fragmented.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the impact of FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on pneumonia susceptibility.
  • To pool data from existing case-control studies for robust statistical analysis.
  • To clarify the association between these specific genetic markers and the risk of developing pneumonia.

Main Methods:

  • Systematic retrieval of case-control studies from multiple online databases.
  • Application of meta-analysis techniques for pooling and analyzing genetic association data.
  • Inclusion of fourteen studies for FCGR2A rs1801274 and thirty-one studies for MUC5B rs35705950.

Main Results:

  • No significant association was found between FCGR2A rs1801274 and pneumonia susceptibility.
  • MUC5B rs35705950 demonstrated a significant association with increased pneumonia susceptibility across various genetic models (allelic, carrier, homozygous, heterozygous).
  • Subgroup analyses confirmed the positive association for MUC5B rs35705950 in Caucasian and Asian populations, and for idiopathic pulmonary fibrosis.

Conclusions:

  • The MUC5B rs35705950 polymorphism is a significant risk factor for pneumonia, especially idiopathic pulmonary fibrosis.
  • FCGR2A rs1801274 does not appear to influence susceptibility to clinical pneumonia.
  • These findings highlight the importance of MUC5B rs35705950 in respiratory disease pathogenesis across diverse populations.
Keywords:
FCGR2AMUC5BPneumoniaSusceptibilityVariation

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