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STK11 mutation status is associated with decreased survival in meningiomas

Corey M Gill1, Joshua Loewenstern2, John W Rutland2

  • 1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. corey.gill@icahn.mssm.edu.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|April 8, 2020
PubMed
Abstract

Insights

STK11 mutations are found in a subset of meningiomas and are linked to a poorer prognosis. Testing for STK11 mutations may guide immunotherapy decisions for meningioma patients.

Area of Science:

  • Oncology
  • Genetics
  • Neurosurgery

Background:

  • Emerging evidence links STK11 mutations to cancer outcomes and immunotherapy response.
  • STK11 gene mutations are increasingly recognized as potential biomarkers in various cancers.

Purpose of the Study:

  • To investigate the prevalence and clinical significance of STK11 mutations in meningiomas.
  • To determine if STK11 mutation status impacts patient survival in meningioma.

Main Methods:

  • Utilized next-generation targeted sequencing to analyze STK11 mutation status.
  • Examined a cohort of 188 patients with meningioma.

Main Results:

  • STK11 loss-of-function mutations were detected in 3.7% of meningiomas across different grades and disease stages.
  • Patients with STK11-mutated meningiomas faced a 2.8-fold increased risk of death.
  • Median overall survival was significantly shorter for patients with STK11 mutations (4.4 years vs. 16.8 years).

Conclusions:

  • Recurrent STK11 mutations characterize a subset of meningiomas.
  • STK11 genotyping is recommended for meningioma patients considered for immunotherapy.
Keywords:
Central nervous systemMeningiomaNeurooncologySTK11Sequencing

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