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Emerging links between endosomal pH and cancer

Myungjun Ko1,2, Alfredo Quiñones-Hinojosa3, Rajini Rao4

  • 1Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD, 21205, USA.

Cancer Metastasis Reviews
|April 8, 2020
PubMed
Summary

Altering endosomal pH, particularly via sodium-hydrogen exchangers (NHE), influences cancer growth and treatment response. Targeting endosomal pH offers a novel therapeutic strategy for various cancers.

Keywords:
And protonsBreast cancerChemoresistanceGlioblastomaNHE6NHE9RACK1Sodium-hydrogen exchanger

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