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Contrast-induced acute kidney injury

Rishi Chandiramani1, Davide Cao1, Johny Nicolas1

  • 1Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY, 10029-6574, USA.

Cardiovascular Intervention and Therapeutics
|April 8, 2020
PubMed

Insights

Contrast-induced acute kidney injury (CI-AKI) is a kidney complication from contrast media. While preventive strategies have lowered rates, further research is needed for evolving interventions.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Minimally invasive cardiology procedures are increasing.
  • Contrast media used in these procedures can cause contrast-induced acute kidney injury (CI-AKI).
  • CI-AKI is a decline in kidney function post-contrast administration.

Purpose of the Study:

  • To review the epidemiology of CI-AKI.
  • To discuss the pathogenesis of CI-AKI.
  • To highlight current and future preventive strategies for CI-AKI.

Main Methods:

  • Literature review of CI-AKI.
  • Analysis of physiological changes in CI-AKI.
  • Evaluation of preventive strategies including hydration, pharmaceuticals, and renal replacement therapy.

Main Results:

  • CI-AKI results from direct nephrotoxicity and oxidative stress.
  • Preventive strategies have reduced CI-AKI incidence.
  • Evolving interventional procedures present ongoing challenges.

Conclusions:

  • CI-AKI remains a significant concern in cardiology.
  • Understanding pathogenesis is key to prevention.
  • Continued research is vital for managing CI-AKI in modern medicine.

Keywords:
Acute kidney injuryContrastNephropathy

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