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Related Experiment Video

Updated: Dec 24, 2025

Evanescent Field Based Photoacoustics: Optical Property Evaluation at Surfaces
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Quenched hexacene optoacoustic nanoparticles.

Antonio Nunes1, Vikram J Pansare, Nicolas Beziere

  • 1Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany. v.ntziachristos@helmholtz-muenchen.de.

Journal of Materials Chemistry. B
|April 8, 2020
PubMed
Summary

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Quenched fluorescent dye nanoparticles offer a powerful alternative to metal nanoparticles for near-infrared optoacoustic imaging. This study introduces novel nanoparticles with enhanced stability and signal generation for deep tissue imaging.

Area of Science:

  • Biomedical Optics
  • Nanotechnology
  • Medical Imaging

Background:

  • Optoacoustic (photoacoustic) imaging provides high-resolution optical imaging deep within tissues.
  • Near-infrared (NIR) operation is crucial for achieving centimeter-scale depths in optoacoustic imaging.
  • Current NIR contrast agents, often metal nanoparticles, have limitations.

Purpose of the Study:

  • To develop and characterize novel organic dye nanoparticles for enhanced optoacoustic signal generation in the NIR region.
  • To explore encapsulation and self-quenching (ESQ) of organic dyes as a strategy for creating potent optoacoustic agents.
  • To establish a comprehensive characterization framework for evaluating optoacoustic nanoparticles.

Main Methods:

  • Flash NanoPrecipitation was employed for scalable, single-step encapsulation of hydrophobic hexacene dye.

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  • A 5-step characterization approach assessed physicochemical properties, optoacoustic signal, stability, biocompatibility, and spectral sensitivity.
  • Nanoparticle formulations (QH2-50 nm and QH2-100 nm) were synthesized and analyzed.

    • Main Results:

    • Two nanoparticle formulations, QH2-50 nm and QH2-100 nm, demonstrated superior stability and optoacoustic properties.
    • These novel nanoparticles outperformed commonly used gold standards for NIR optoacoustics.
    • The ESQ strategy proved effective for generating strong optoacoustic signals from organic dyes.

    Conclusions:

    • Quenched fluorescent dye nanoparticles are a promising alternative to metal nanoparticles for NIR optoacoustic imaging.
    • The ESQ approach offers a viable strategy for developing advanced optoacoustic contrast agents.
    • The developed nanoparticles show potential for revolutionizing deep-tissue optical interrogation.