Related Experiment Video
Updated: Dec 24, 2025
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Graphene oxide coating core-shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and
Yuan-Yang Song1, Cheng Li, Xiao-Quan Yang
1Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Collaborative Innovation Center for Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China. zydi@mail.hust.edu.cn chen1980wei@mail.hust.edu.cn.
Abstract:
The accurate treatment of tumors with the help of multimodality imaging is of great significance. Herein, a novel multifunctional probe combining active targeted fluorescent imaging (FL)/photoacoustic imaging (PA) and chemo-photothermal therapy for tumors has been designed. Targeting molecule folate (FA) modified graphene oxide (GO) was used to coat core-shell silver sulfide@mesoporous silica (QD@Si) while antitumoral doxorubicin (DOX) was loaded in mesoporous channels by electrostatic adhesion, and a delivery system (QD@Si-D/GO-FA) for active targeted dual-mode imaging and synergistic chemo-photothermal for tumors was successfully obtained. Experiments showed the cell survival rate was 76.3 ± 4.6% when the probe concentration reached 0.5 mg mL-1, and demonstrated that the probe had good biocompatibility. In vivo and in vitro results indicated that this probe could be used for active targeted FL/PA for tumors with overexpressed FA receptors. The temperature of the tumor rose to 63.5 °C under laser irradiation, and the tumor could be killed more effectively after combination with chemotherapy, which was caused by exfoliation of GO from QD@Si-D/GO-FA after irradiation. These results showed that the probe had great potential for application in oncology and is expected to provide evidence for early diagnosis and treatment of tumors.
Insights
This study introduces a novel multifunctional probe for dual-mode imaging and combined chemo-photothermal therapy of tumors. The probe demonstrates effective tumor targeting and treatment, showing great potential for oncology applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Accurate tumor treatment requires advanced imaging and therapeutic strategies.
- Multimodality imaging offers enhanced diagnostic capabilities for tumors.
- Developing multifunctional probes is crucial for targeted cancer therapy.
Purpose of the Study:
- To design a novel multifunctional probe for active targeted fluorescent/photoacoustic imaging and chemo-photothermal therapy of tumors.
- To evaluate the probe's biocompatibility, targeting efficiency, and therapeutic efficacy.
- To investigate the synergistic effects of combined therapies for tumor treatment.
Main Methods:
- Synthesis of a core-shell silver sulfide@mesoporous silica nanoparticle coated with folate-modified graphene oxide (QD@Si-D/GO-FA).
- Loading of doxorubicin into mesoporous channels for chemotherapy.
- Utilizing fluorescent and photoacoustic imaging for tumor visualization.
- Employing laser irradiation for photothermal therapy and assessing synergistic effects.
Main Results:
- The probe (QD@Si-D/GO-FA) exhibited good biocompatibility with a cell survival rate of 76.3 ± 4.6% at 0.5 mg mL⁻¹.
- Effective active targeted fluorescent/photoacoustic imaging of tumors overexpressing folate receptors was achieved.
- Laser irradiation elevated tumor temperature to 63.5 °C, leading to enhanced tumor killing when combined with chemotherapy due to graphene oxide exfoliation.
Conclusions:
- The developed multifunctional probe shows significant potential for active targeted dual-mode imaging and synergistic chemo-photothermal therapy in oncology.
- The probe facilitates early diagnosis and effective treatment of tumors.
- This approach offers a promising strategy for integrated cancer management.
More Related Videos
06:42Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
Published on: May 9, 2025
07:26Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
Published on: November 20, 2018
