Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

143
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
143
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

6.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.0K
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.4K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.4K
Drug Delivery: Overview01:16

Drug Delivery: Overview

652
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
652

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visible-Light HAT Photocatalysis for Switchable Polyethylene Degradation and C-H Functionalization.

ACS macro letters·2026
Same author

HSP47 is a potential dual cell target and prognostic factor in pancreatic cancer.

Oncogene·2026
Same author

3D-Printable Nanoporous Thermosets via Disulfide-Based Polymerization-Induced Microphase Separation.

Angewandte Chemie (International ed. in English)·2026
Same author

Conjugation of Antibiotics to Peptidomimetics Enhances Antimicrobial Spectrum of Activity.

Antibiotics (Basel, Switzerland)·2026
Same author

Additive Manufacturing of Ordered Polymer Nanostructures.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer.

Cell death & disease·2026

Related Experiment Video

Updated: Dec 24, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.7K

Recent advances in nitric oxide delivery for antimicrobial applications using polymer-based systems.

Zahra Sadrearhami1, Thuy-Khanh Nguyen, Rashin Namivandi-Zangeneh

  • 1Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW Australia, Sydney, NSW 2052, Australia. cboyer@unsw.edu.au.

Journal of Materials Chemistry. B
|April 8, 2020
PubMed
Summary

Nitric oxide (NO) releasing polymers show promise for fighting bacterial biofilms. This review covers advancements in NO-releasing biomaterials for antimicrobial applications and future challenges.

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K

Related Experiment Videos

Last Updated: Dec 24, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.7K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.6K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K

Area of Science:

  • Biomaterials Science
  • Antimicrobial Research
  • Polymer Chemistry

Background:

  • Nitric oxide (NO) is increasingly recognized for its potential in treating biofilm-associated bacterial infections.
  • Current limitations include low NO loading, short half-lives of NO donors, and challenges in targeted delivery.
  • Combining NO with biocompatible polymer scaffolds offers a promising strategy to overcome these limitations.

Purpose of the Study:

  • To review recent developments in nitric oxide-releasing polymeric biomaterials.
  • To focus on the application of these materials in antibiofilm treatments.
  • To identify current challenges and future directions in the field.

Main Methods:

  • Literature review of recent scientific publications on NO-releasing polymeric biomaterials.
  • Analysis of studies focusing on antimicrobial and antibiofilm efficacy.
  • Discussion of synthesis, characterization, and in vitro/in vivo performance of these materials.

Main Results:

  • Polymeric biomaterials can be engineered to effectively load and release nitric oxide.
  • NO-releasing polymers demonstrate significant potential for combating bacterial biofilms.
  • Various polymer architectures and NO-releasing strategies have been explored.

Conclusions:

  • NO-releasing polymeric biomaterials represent a viable approach for advanced antimicrobial therapies.
  • Further research is needed to address challenges in stability, controlled release, and clinical translation.
  • These materials hold significant promise for future biomedical applications, particularly in infection control.