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Internalization studies on zeolite nanoparticles using human cells.

Natália Vilaça1, Ricardo Totovao, Eko Adi Prasetyanto

  • 1Centre of Chemistry, Chemistry Department, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. ineves@quimica.uminho.pt.

Journal of Materials Chemistry. B
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

Zeolite L nanoparticles are rapidly internalized by both normal and breast cancer cells, with significantly higher uptake observed in cancer cells. This cellular uptake is primarily mediated by caveolin-dependent endocytosis.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Cell Biology

Background:

  • Zeolites are porous crystalline materials with potential applications in biomedical fields like cell imaging and drug delivery.
  • Understanding zeolite nanoparticle-cell interactions is crucial for optimizing their use, as internalization mechanisms remain unclear.

Purpose of the Study:

  • To investigate the intracellular trafficking and internalization kinetics of zeolite L nanoparticles.
  • To compare zeolite L uptake in breast cancer cells versus normal epithelial mammary cells.
  • To elucidate the endocytic pathways involved in zeolite L internalization.

Main Methods:

  • Utilized scanning electron microscopy (SEM), confocal microscopy, and transmission electron microscopy (TEM).
  • Employed pharmacological inhibitors (chlorpromazine and dynasore) to study endocytic pathway involvement.
  • Analyzed nanoparticle localization within cells.

Main Results:

  • Zeolite L nanoparticles were rapidly internalized by both cell types, beginning within 5 minutes.
  • Uptake was significantly faster and more efficient in breast cancer cells compared to normal mammary cells.
  • Internalized nanoparticles were predominantly found within cellular vacuoles, suggesting caveolin-mediated endocytosis.

Conclusions:

  • Zeolite L nanoparticles exhibit differential uptake kinetics dependent on cell type, favoring cancer cells.
  • The internalization of zeolite L nanoparticles into cells is primarily mediated by caveolin-dependent endocytosis.
  • These findings provide insights into zeolite-cell interactions for enhanced biomedical applications.